Buy Fentanyl 10x 50mcg online
Buy Fentanyl 10x 50mcg
Buy fentanyl (1-phenethyl-4-N-propionylanilinopiperidine) is a very strong opioid agonist with short-term effect. It is believed to be up to 75–100 times stronger than morphine, but most closely affects the µ-opioid receptors in the central nervous system. Fentanyl is used as a medicine to relieve very severe pain and in anesthesia.
For the purpose of intoxication, a euphoric and sedative effect of fentanyl is sought, although the euphoria created is considered to be milder than that created by morphine. Repeated use of fentanyl quickly leads to increased tolerance and physical dependence. The toxicity of fentanyl is also mediated by the opioid receptors. The most common symptoms of intoxication include respiratory depression, central nervous system inhibition (coma), muscle stiffness and small pupils (miosis). In addition, the heart rate slows down, blood pressure drops and bowel movements are inhibited. Urine excretion is also reduced. Withdrawal symptoms are typical opioid withdrawal symptoms (including muscle aches, colds, tremors, restlessness, anxiety, nausea), but can be exceptionally severe. Buy Fentanyl,
Risks of intoxication
Due to the strength of the fentanyl is the risk of overdoselarge, and fatal respiratory depression can occur rapidly. If pain patches containing fentanyl (Durogesic®, Matrifen®, Fentanyl® [many manufacturers]) are used in an abnormal way, for example if you suck on or swallow patches or pieces of plaster, extract the substance in liquid and use the liquid intravenously, it causes a special big risk. The dose of fentanyl ingested is unknown, Buy Fentanyl but the effect can set in very quickly, which is life threatening. If the strongest patches are used on the skin, they can be dangerous for people who are not used to opioids, especially if they are “forgotten” left on the skin when you go to bed at night. A change in the properties of the skin (including the effect of temperature on the bloodstream) can increase the absorption of the drug by up to 30 percent and then lead to a poisoning condition.
The drug users who cut the patches can estimate the amount of fentanyl that the piece provides by setting the size of the piece in proportion to the size of the patch. The result can only be considered as a very rough indicative estimate, and in no case as a recommended method. When the patches are cut into pieces, the depot structure is destroyed, which can lead to uncontrolled release of fentanyl from the patch. The fentanyl patches of the different manufacturers also have different properties, and between the different strengths there are differences in the sizes. Attempts have been made to improve the safety of the patch by incorporating the fentanyl into the structure of the patch instead of placing it in a special depot in the patch.
Mixed use with other substances that inhibit the central nervous system, such as benzodiazepines, alcohol or other opioids, increases the risk of overdose. In the body, fentanyl is mainly dissolved by the liver’s CYP3A4 enzyme, and therefore drugs and compounds that affect the activity of the enzyme in question can increase or in some cases reduce the fentanyl content in the body. ®) and injection form (Fentanyl® [many manufacturers]).
Estimation of the dose
It is estimated that 1 milligram of morphine corresponds to 0.01 milligrams (ie 10 micrograms) of fentanyl in subcutaneous and intravenous use. When fentanyl is ingested through the mucous membranes of the mouth, its effect is estimated at 40–70 percent compared with intravenous use. If the strength of the patch is, for example, “25 micrograms / hour”, this means in practice that 25 micrograms of fentanyl is released during one hour. The patch is usually used for 72 hours, ie. the total dose of fentanyl during this time is 25 micrograms / hour x 72 hours = 1,800 micrograms, ie. 1.8 milligrams. This is an 18-fold greater dose than the intravenous dose (100 micrograms) given during anesthesia (and thus in resuscitation readiness). The dose of the strongest patch (100 micrograms / hour) is up to 72 times higher. A fentanyl dose of 2 milligrams is considered fatal,
In intravenous use, the effect sets in almost immediately and reaches its peak within a few minutes. In pain treatment, it is estimated that the analgesic effect lasts for a maximum of about 30-60 minutes. Prolongation of the effect by increasing the dose easily leads to a lethal single dose, and therefore fentanyl is dosed in healthcare repeatedly or as a continuous infusion or in the form of transdermal patches. The effect of the patch is slowly enhanced for several hours, and an even level in the blood is achieved within 12-24 hours. The harmful effects also arise with delay. Buy Tramadolor
Impaired breathing is an alarming sign of an imminent overdose. The overdose can be effectively reversed with opioid antagonists, for example with a naloxone injection, but the start of treatment must not be delayed. According to information in the discussion columns, some users have a buprenorphine injection ready for a possible overdose. Buprenorphine is a partially agonistic opioid. There is no research information on its effect in the acute treatment of fentanyl overdose. Naloxone should therefore be considered as the only antidote. Since 2006, more than 30 deaths have been linked to fentanyl in Finland. In many cases there has also been mixed use of drugs in the background, but in some cases the deceased have been aware of how exceptionally dangerous fentanyl is.
If overdose is suspected, the public emergency number (112) or the Poison Information Center (09-471 977) should be contacted immediately. There is reason to start resuscitation immediately, and continue this until the care staff has arrived.